Even in small dosages, many users reported gastro-intestinal problems such as bloating, nausea, skin rash and itching (hives), black, tarry stools or light-colored stools, depression, unusual bleeding, unusual swelling, yellowing of the eyes or skin, and diarrhoea. Other studies however have shown links between prolonged use of the drug and problems of liver toxicity similar to those found with other 17α-alkylated steroids. Those treated with Oxandrolone showed improve body composition, preserved muscle mass and reduced hospital stay time. In a randomized, double-blind study, patients with 40% total body surface area burns were selected to receive standard burn care plus Oxandrolone, or without Oxandrolone. In addition, the drug has shown positive results in treating anaemia and hereditary angioedema. It was approved for orphan drug status by the Food and Drug Administration (FDA) in treating alcoholic hepatitis, Turner's syndrome, and weight loss caused by HIV. who, following successful clinical trials in 1995, released it under the tradename Oxandrin. It was picked up by Bio-Technology General Corporation, now Savient Pharmaceuticals, Inc. However, in part due to bad publicity from its abuses by bodybuilders, Oxandrolone was discontinued by Searle Laboratories in 1989. It had also been shown to be partially successful in treating cases of osteoporosis. The drug was prescribed for a number of medical disorders causing involuntary weight loss, in order to promote muscle regrowth. Lack of PCT will of course lead to protein catabolism until body's normal testosterone secretion is back to normal. Post Cycle Therapy (PCT) is of course needed for high dosages (40-50mg) of this synthetic derivative of testosterone because as the dosage increases the influence on HPTA is bigger. When dosages are high (this goes for any anabolic steroid) then your body feels that it has enough testosterone and it reduces the production of LH (luteinizing hormone) which no longer stimulates Leydig cells in testicles to produce testosterone therefore causing testicular atrophy (shrinking). What is the Correct Way to Check Repeatability in Balances?Īs opposed to most other anabolic steroids Oxandrolone has two major advantages: First of all it does not aromatize (convert to estrogen which causes gynecomastia - breast tissue) and it does not significantly influence on low dosages (10mg) body's normal testosterone production (HPTA axis).
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